I know, I feel the same way, at least emotionally. But after I read up on long-term side effects of steroids online back around 2002 I decided to stop all use of topical corticosteroids on my psoriasis. I had years of rebound flares after that, worse symptoms than I'd ever had before. It finally calmed down when I quit my job and moved to the country. But as soon as I stated dating and felt the usual anxiety , my face would redden, swell and burn during each first date. I was a mess for years until I settled in with my final man. I don't know whether this means I never should have started using prescription creams back in my teens or I shouldn't have gone off them cold-turkey. But when a psoriasis flare subsides the skin is like new again. LS, on the other hand, leaves disfigurement in its wake. So that's why I haven't even though about trying this drug-free.
Cushing's syndrome has been reported in infants and adults as a result of prolonged use of topical clobetasol propionate formulations. The following additional local adverse reactions have been reported with topical corticosteroids, and they may occur more frequently with the use of occlusive dressings and higher potency corticosteroids. These reactions are listed in an approximately decreasing order of occurrence: dryness, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, irritation, striae, and miliaria.
Like other topical corticosteroids, clobetasol propionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A 2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor , arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.