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Patients should be advised not to wear a contact lens if their eyes are red. Patients should be advised that PATADAY™ (olopatadine hydrochloride ophthalmic solution) solution should not be use to treat contact lens-related irritation. Patients should also be advised to remove contact lenses prior to instillation of PATADAY™ (olopatadine hydrochloride ophthalmic solution) solution. The preservative in PATADAY™ (olopatadine hydrochloride ophthalmic solution) solution benzalkonium chloride may be absorbed by soft contact lenses. Lenses may be reinserted following administration of PATADAY™ (olopatadine hydrochloride ophthalmic solution) solution.

Dutasteride (Avodart) has more complete suppression of all three 5α-reductase isoenzymes. It inhibits types 1 and 2 better than finasteride, leading to it causing further reduction in DHT at 6 months than the older drug (% versus %). [27] It also reduces intraprostatic DHT 97% in men with prostate cancer at 5 milligrams per day over three months. [28] A second study with  mg/d for 4 months decreased intraprostatic DHT even further by 99%. [29] It has also been shown to inhibit the 5α-R3 isoenzyme in vitro , [30] suggesting that dutasteride may be a triple 5α reductase inhibitor in vivo . [16]

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