When Matt Damon was filming The Martian (2015), he wanted to lose 30 to 40 pounds to portray astronaut Mark Watney after he had been surviving on meager rations for years. But the filming schedule made that impossible, so a body double had to be brought in for some shots. “I was going to lose a bunch of weight in the third act of the movie, then put the weight back on,” Damon told Maclean’s . However, as the schedule shook out, they filmed the NASA interiors in Hungary, then immediately went to Jordan, which doubled as the Red Planet for the film’s purposes, and shot all the exterior shots from the beginning, middle, and end of the movie, with no time for Damon to lose a significant amount of weight. The skinny body double isn’t on screen for long. “It was, like, two shots,” Damon describes. (Still, fans noticed .)
Many people who are addicted to drugs are also diagnosed with other mental disorders and vice versa. Compared with the general population, people addicted to drugs are roughly twice as likely to suffer from mood and anxiety disorders, with the reverse also true. In 2015, an estimated million ( percent) adults ages 18 and older experienced some form of mental illness (other than a developmental or substance use disorder). Of these, million had both a substance use disorder and another mental illness. 1 Although substance use disorders commonly occur with other mental illnesses, it’s often unclear whether one helped cause the other or if common underlying risk factors contribute to both disorders.
The areas of the brain where cannabinoid receptors are most prevalently located are consistent with the behavioral effects produced by cannabinoids. Brain regions in which cannabinoid receptors are very abundant are the basal ganglia , associated with movement control; the cerebellum , associated with body movement coordination; the hippocampus , associated with learning , memory, and stress control; the cerebral cortex , associated with higher cognitive functions; and the nucleus accumbens , regarded as the reward center of the brain. Other regions where cannabinoid receptors are moderately concentrated are the hypothalamus , which regulates homeostatic functions; the amygdala , associated with emotional responses and fears ; the spinal cord , associated with peripheral sensations like pain; the brain stem , associated with sleep , arousal , and motor control; and the nucleus of the solitary tract , associated with visceral sensations like nausea and vomiting .